Abstract The serendipitous discovery that inhibiting type 5 phosphodiesterase (PDE5) using sildenafil, a potent PDE5 inhibitor (PDE5i) initially developed for cardioprotection, introduced the possibility of orally managing erectile dysfunction (ED) led to an increase in research data, which are currently considered groundbreaking for the new discip
Diffuse large B-cell lymphoma with contemporary involvement of central and peripheral nervous system: A case report and literature review
Introduction: Simultaneous involvement of the peripheral nervous system (PNS) and central nervous system (CNS) during the same period in diffuse large B-cell lymphoma (DLBCL) is rarely documented.In this particular case, the diagnosis of diffuse large B-cell lymphoma was pathologically confirmed, with invasion into the basal ganglia, diencephalon,
Structures of Omicron spike complexes and implications for neutralizing antibody development
Summary: The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries worldwide.The high number of spike mutations is responsible for the broad immune evasion from existing vaccines and antibody drugs.To understand this, we first present the cryo-electron microscopy structure of ACE2-bound SARS-CoV-2 Omicron spike.Comparison to pre
COMPARATIVE FEDERALISM WITH REFERENCE TO CONSTITUTIONAL MACHINERY FAILURE (EMERGENCY) IN INDIA AND PAKISTA
The constitutions and courts both in India and in Pakistan have shown their aspirations and fundamental faith in the federal structure but in practice there is a strong centripetal bias in each of their constitutional-political structures.This bias becomes more evident when the constitution sanctions power to the centre to superdry baseball top pro